Hawthorne Berries are gathered from the small tree Crataegus laevigata of the family Rosaceae. Also known as Mayblossom and Whitehorn, Hawthorne was known to Dioscorides in the first century A.D., but was not widely used until recent times. The edible berries are often made into marmalade, and herbal preparations made from the flowers, fruits, and leaves are very prominent in contemporary European medicine. Currently about three dozen different preparations containing extracts of Hawthorne are marketed in Germany.
Hawthorne is described in most modern herbals as a valuable treatment for various heart ailments and circulatory disorders, as well acting as a mild astringent to be used for treating sore throats. Hawthorne is most often used to protect against the beginning stages of heart disease, for mild heart muscle weakness, for pressure and tightness of the chest, and for mild arrhythmia. It is also used as a tonic for an aging heart.

Standardized extracts improve myocardial and coronary circulation, raising the myocardial tolerance for oxygen deficiency. Hawthorne is also used for hypertension, nervous disorders and insomnia. It may potentate the action of digitalis, and does potentate cardiotonic glycosides.
Hawthorne should not be used as a substitute for medical care when an "organic cause" for one of the conditions listed is present, so cause should be diagnosed prior to use.
Modern researchers have revealed some interesting properties of Hawthorne and confirmed that Hawthorne contains compounds which support the heart and circulatory system. Hawthorn works to dilate the blood vessels, especially the coronary vessels, reducing peripheral resistance and thus lowering blood pressure and reducing the tendency to angina attacks. Though Hawthorne's action is not immediate, but develops very slowly, apparently it has a direct effect on the heart itself, especially in cases of heart damage. Its toxicity is low as well, becoming evident only in large doses. It's therefore a relatively harmless heart tonic which apparently yields good results in many conditions where this kind of therapy is required.

Hawthorne contains leucoanthocyanins, flavonoids, hyperoside, vitexin 2-rhamnoside, glycosylflavones, amines, catechols, phenolcarboxylic acids, triterpene acids, sterols, inositol, PABA, saponins and purines. The main activity of Hawthorne is derived from the potent mixture of pigment bioflavonoids, as well as oligomeric procyanidins (dehydrocatechins) that seem to be particularly active. Some of the flavonoid glycosides are thought to work in a similar way to digitoxin, having a vasodilating effect that could be helpful in the treatment of angina. They also produce marked sedative effects which indicate an action on the central nervous system.
A combination of several constituents seems to be directly responsible for the increase in heart muscle contraction force, by blocking whatever is reducing the contraction, for example, beta-blockers. The flavones help control the intracellular Calcium ion concentration. Hawthorne berries also contain inositol, PABA, purines, saponins, and B vitamins.

The Hop plant, Humulus lupuius, is a perennial climbing vine and hedgerow that twines around trees. Belonging to the family Cannabidaceae, Hops are extensively cultivated in England, Germany, the United States, South America, and Australia. The Hop plants bear a female strobile (fruit) shaped like a scaly cone, covered with glandular hairs containing the resinous bitter principles which make Hops so popular in brewing and in medicine. Hops have been used since Roman times in brewing beer and as a nerve tonic and sedative. It has also been used to control diarrhea, irritable bowel syndrome and Crohn's disease, where spasms of the smooth muscles play a role.

Although Hops have been used for brewing beer for over 1,000 years, their medicinal properties have also been valued from very early times. Hop pickers used to tire easily, apparently as a result of transferring some Hop resin from their hands to their mouths, gaining Hops a reputation as a safe sedative. Later, pillows filled with Hops were used for insomnia and nervousness. Small bags of Hops, wetted with alcohol and placed on the skin, were also said to reduce local inflammation.

Experiments have shown that Hops relaxes the smooth muscles and acts as a sedative. It has been used to increase breast milk for irritable infants (and probably pass along its soothing effects).
The main constituent chemicals are unstable polyphenolic principles, primarily lupulin, which contains a bitter acid complex (2-Methyl-3-butonol, humulone, lumulone, lupulone and valeronic acid) and a volatile oil complex (humulene, myrcene, b-carophyllene and farnescene). The bitter acids humulone and lupulone have been associated with sedative properties. Hops also contain tannins, flavonoid glycosides (rutin, quercetin and astragalin), and asparagine.

CAUTION: If you are pregnant or nursing, consult your  professional before using Hops products. Not recommended for people suffering from depressive illness.
SUPPORTIVE AGENTS: Valerian, Passion Flower, Chamomile, Skullcap, Kava Kava, Wood Betony, Hawthorne Berries, L-Trytophan, GABA.

Kava Kava (Piper Methysticum), also known as kava pepper, is an exciting botanical that has gained recent popularity in United States due to its availability. Though Kava is relatively new to the U.S., it is certainly not a new herb. Kava has been used in Polynesia, Melanesia and Micronesia in the South Pacific for over 3,000 years. Kava is a relaxant and sleep aid, able to induce a feeling of relaxation, peace and contentment, along with a sharpening of the senses. Kava was the beverage of choice during important meetings involving conflicts, inducing a state of relaxation and goodwill among parties trying to reconcile differences.

More recently, in the past few hundred years, Kava has also gained popularity with the natives of Hawaii, Australia and New Guinea where it is used medicinally as well as recreationally.
Kava was first mentioned in the scientific records in 1886, and by 1993 the active ingredients, Kavalactones, were detected by mass spectrometry. Over the past 100 years extensive analytical investigation of the Kava root has revealed that the active ingredients in Kava, the kavalactones, comprise 15% of the root. Of the fifteen lactones isolated from Kava, there are six major lactones (kavalactones) known to provide psychoactive activity: kawain, methysticin, demethoxy-yangonin, dihydrokawain, dihydomethysicin, and yongonin. All kavalactones are physiologically active, though it is the fat-soluble kavalactones derived from kava resin that convey the main psychoactive activity.

Absorption in the gastrointestinal tract is remarkably rapid, so the effects are felt almost immediately. The kavaclones are pharmacologically effective and differences in their actions are qualitative as well as quantitative. According to Singh (1983), "Kavalactones act less by inhibition of neuromuscular transmission than by a direct effect on muscular contractility. The postsynaptic depression is similar to that caused by lignocain and other local anesthetics". Kava's muscle-relaxant properties are similar to those of potent tranquilizers as they both act on the central nervous system. Double-blind, placebo controlled studies conducted in 1991 show Kava to be a modern means of achieving relaxed states without side effects.
Increased cognitive function has been observed with Kava use according to a 1993 article in

Neuropsychobiology. Unlike sedatives, Kava improves mental function instead of "dulling the brain. And unlike alcohol or sedatives, it would be extremely difficult to build up a tolerance to Kava (Clinical and Experimental Pharmacology, 1992, 18:571). A dose of 100 to 150 of Kava can induce sleep within 30 minutes. No aftereffects are noted at this dose. Kava root is primarily used as a natural sedative and sleep inducer. It is also effective in reducing menstrual cramps. Kava is obviously not recommended for those who intend to drive or conduct any activity which requires fast reaction time.
Pharmaceutical grades of natural Kava root are available from reputable companies in the United States. Synthetic Kava can be produced but does not possess the same soothing qualities of naturally extracted kavalactones from the Kava plant. Correctly extracted Kava will contain all six kavalactones in high concentrations (25-30%).

CAUTION: Driving or operating heavy or dangerous equipment is not recommended while under the influence of Kava Kava, as drowsiness is likely to occur. Kava Kava use is contraindicated during pregnancy or nursing, and in cases of depression. Do not take for more than 3 months, or more than 1,000 mg. per day without medical advice. Extended continuous intake can cause a temporary yellow discoloration of skin, hair and nails, in which case it must be discontinued. Discontinue use if dilation of pupils or disturbances of coordination between vision and movement occur.
INTERACTION: Use of Kava Kava may increase the effects of alcohol, barbiturates and psychopharmacological agents.

Licorice Root has been used by the Chinese for over 5,000 years. It is used to treat coughs, sore throats, malaria, food poisoning, respiratory problems, liver and uterine complaints, fevers, inflammation, hoarseness, stomach problems, and bladder and kidney ailments.
While commonly thought of as a popular candy, the herb Licorice is derived from the from the roots and stems of the plant Glycyrrhiza glabra, and is never used in candies. Licorice is one of the mainstays of traditional Chinese medicine, and has also been used for over 3,000 years as a tonic to rejuvenate the heart and spleen, and as a treatment for ulcers, cold symptoms, and skin disorders.

Modern herbalists commonly utilize licorice in treating adrenal insufficiencies such as hypoglycemia and Addison's disease, counteracting stress, and in purifying the liver and bloodstream. In combination with other herbs, it is recommended as a demulcent to soothe mucous membranes, and as an expectorant useful in treating flu, colds, respiratory disorders and bronchitis.

Licorice Root is a time-honored remedy for arthritis due to its anti-inflammatory properties; it stimulates the production of two natural steroids: cortisone and aldosterone. It also acts as a demulcent, diuretic, expectorant, and laxative. Licorice also stimulates the production of bile by the liver and can relieve stomach aches and ulcers. We also know that this herb can also lower cholesterol.

The National Cancer Institute is investigating compounds derived from Licorice Root for their capability to inhibit growth of cancerous cells and prevent tooth decay.
Medical researchers have isolated several active substances in licorice root including glycosides, flavonoids, asparagine, isoflavonoids, chalcones and coumarins. Primary of these is Glycyrrhetinic acid, a natural anti-inflammatory compound that led to the successful development of drugs used in the treatment of duodenal and gastric ulcers, as well as ulcers of the mouth and genitals.
Another licorice compound, glycyrrhizin, has been shown to possess anti-viral properties effective against the polio virus, herpes zoster, herpes simplex, and the HIV virus. Both compounds have also been found to inhibit cancer cells in vitro, though clinical studies on humans have not been conducted.

Other derivatives of licorice have elicited a host of active ingredients that seem to act as anti-depressants and, if that weren't enough, inhibit the enzymes that cause tooth decay. All in all licorice is a very impressive herb that is well supported by medical research and clinical data.
Persons with a history of congestive heart failure, kidney disease, and liver disorders should not use licorice compounds. If you are pregnant or nursing, consult your health care professional before using this product. People with a history of renal failure or those currently using cardiac glycosides may wish to avoid use of Licorice as a precautionary measure.
It contains Vitamins E,  B-complex, phosphorous, biotin, niacin,  pantothenic acid, lecithin, manganese, iodine, chromium, and zinc.



Hawthorne Berries
Hop
Kava Kava
Licorice
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